人类肿瘤中约10%～15%的染色体端粒酶无活性,其中部分病例端粒长度是通过替代性端粒延长(ALT)重组机制来维持的。ALT表型普遍存在于某些肉瘤和生殖细胞肿瘤中,而在癌中却很少见。本研究证实了乳腺癌中有ALT表型的分子亚型存在,尤其是在HER-2过表达的乳腺癌亚型中。我们用组织芯 About 10% to 15% of human telomerase telomerase activity is inactive, and in some cases telomere length is maintained by alternative telomere elongation (ALT) recombination mechanisms. The ALT phenotype is prevalent in some sarcomas and germ cell tumors, but rare in cancer. This study confirms the presence of a molecular subtype of ALT phenotype in breast cancer, especially in breast cancer subtypes overexpressing HER-2. We use tissue cores