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当亲水的水溶性基质接触水溶液后,就形成了一层假胶状膜,这层膜控制了片子的溶蚀和药物向周围液体扩散的速率。Willis及其同工作者测定了双氯灭痛静脉给药和口服给药的药物动力学。该药动力学的特性曲线提示,以控制药物吸收来达到延长周期,保证几乎是恒定的血药水平,并具有较小的毒副作用是有可能的。本文拟介绍双氯灭痛控释片的研究。方法为使双氯灭痛从控释片中释放达12h以上,应用Robinson和Eriksen方程,根据所报道的药动学数据计算其修正剂量和维持剂量分别为16.5mg和96.0mg.
When the hydrophilic, water-soluble matrix contacts the aqueous solution, a layer of pseudocolloidal film is formed which controls the dissolution of the film and the rate of drug diffusion to the surrounding liquid. Willis and colleagues determined the pharmacokinetics of diclofenac both intravenously and orally. This pharmacokinetic profile suggests that it is possible to control drug absorption to achieve prolonged periods, to ensure almost constant plasma levels and with less toxic side effects. This article intends to introduce diclofenac controlled release tablets. Methods To release diclofenac from controlled release tablets for more than 12h, the modified dose and the maintenance dose were calculated to be 16.5mg and 96.0mg based on reported pharmacokinetic data using Robinson and Eriksen equations respectively.