核转录因子 (nuclearfactor κB)最初是从B细胞核提取物中发现的一种能与免疫球蛋白κ轻链基因的增强子κB序列特异结合的蛋白因子 ,后证明其广泛存在于淋巴细胞和非淋巴细胞中。在细胞受到炎症介质、病毒感染、氧化应激等多种刺激后 ,NF κB可被激活 ,从而启动相关基因的转录 Nuclear factor κB (NF-κB) was originally found in nuclear extracts of B cells as a protein factor that specifically binds to the enhancer κB sequence of the immunoglobulin κ light chain gene. It has been shown to be widespread in lymphocytes and non-lymphoid Cells. After the cells are stimulated by inflammatory mediators, virus infection, oxidative stress and other stimuli, NF κB can be activated to initiate the transcription of related genes