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Objective:To investigate the antidiabetic and anti-lipemic effects ofCassia siamea methanolic leaves extract.Methods: The antidiabetic study was performed by measuring blood glucose level with elegance glucometer at weekly intervals i.e.0, 7, 14 and21 in normal and streptozotocin induced diabetic rats. Total cholesterol, triglyceride andHDL-cholesterol were determined in normal and streptozotocin induces diabetic rats by autoanalyser. Glibenclamide was used as a reference drug at a dose of10 mg/kg.Results: After the oral administration of extracts at doses of250 mg/kg and500 mg/kg for three weeks, blood glucose levels and body weights were significantly improved (P<0.01). Daily oral treatment with the extract also resulted in significantly reduction of serum cholesterol and triglycerides.HDL-cholesterol level was found to be improved to (P<0.01).Conclusions: TheCassia siamealeaf extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetes.