幽门螺杆菌(Hp)可导致慢性活动性胃炎,与消化性溃疡和胃癌密切相关。鸟氨酸脱羧酶(ODC)是多胺生物合成限速性的第一步,是正常细胞和肿瘤生长所需要的一种独特的细胞内基质。因此,本研究检测Hp感染者胃粘膜的ODC活力推测其与炎症严重程度和Hp所致的癌前病变的关系。 方法:75例因消化不良而接受胃镜检查的病人胃窦部取6块活检标本用于组织学检查和 Helicobacter pylori (Hp) can cause chronic active gastritis, which is closely related to peptic ulcer and gastric cancer. Ornithine decarboxylase (ODC) is the first step in the rate-limiting polyamine biosynthesis and is a unique intracellular matrix required for normal cell and tumor growth. Therefore, the present study examined the ODC activity of gastric mucosa in Hp infected individuals and hypothesized that it correlates with the severity of inflammation and Hp-induced precancerous lesions. Methods: Seventy-five biopsies from 75 patients with gastroscopy due to dyspepsia were taken for histological examination and