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目的 :测试氯葡栓的皮肤刺激性和慢性毒性。方法 :采用豚鼠皮肤致敏试验和家兔阴道接触药物的慢性毒性实验。结果 :皮肤致敏试验用药部位未见红斑、水肿等皮肤致敏反应。慢性毒性实验用药组家兔一般行为活动、体重增长、血液学、血液生化、主要器官脏器指数等指标与对照组比较差异均无显著性 (P >0 .0 5 ) ;病理学切片检查 ,各主要组织器官均未见中毒性病理改变。结论 :氯葡栓无明显皮肤刺激性和慢性毒性作用 ,局部用药较为安全
Objective: To test the skin irritation and chronic toxicity of clofibrate. Methods: The chronic toxicity test of guinea pig skin sensitization test and vaginal contact drug were used. Results: Skin sensitization test site no erythema, edema and other skin sensitization. Chronic toxicity experimental group rabbits general behavioral activities, weight gain, hematology, blood biochemistry, the main organ index and other indicators were not significantly different from the control group (P> 0.05); pathological biopsy, No major toxicological changes were found in all major tissues and organs. Conclusion: Clofibrate has no obvious skin irritation and chronic toxicity, and local administration is safer