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目的:了解国内外关于社区老年慢性病患者的用药审查干预的实施策略、运行进展、干预效果及出现的问题,为开展相关研究提供决策建议。方法:采用系统评价的方法对2005-2010年国内外公开发表的关于老年用药相关问题的用药审查干预的文献进行检索及评价。结果:共计8项研究纳入系统分析,累计干预人群863例,对照人群899例,涉及4个国家;干预的时间为8周~2年;干预的评价指标主要有从用药相关、患者相关、健康及生命质量相关这三个方面。结论:以药师为主导的用药审查对提高患者生命质量、降低住院率和死亡率无显著性影响,对精简用药数量,确定药学服务主题,提高患者药物治疗收益有较好的效果。
OBJECTIVE: To understand the implementation strategies, operational progress, the effects of interventions and the emerging problems of the drug review and intervention interventions in elderly people with chronic diseases in the community both at home and abroad, so as to provide decision-making suggestions for carrying out related research. Methods: A systematic review was conducted to search and evaluate the published literature on interventions for drug use related to senile medication from 2005 to 2010. Results: A total of 8 studies were included in the systematic analysis. There were 863 cumulative interventions, 899 control subjects, and 4 interventional countries. The intervention duration ranged from 8 weeks to 2 years. The evaluation indicators of the intervention mainly included drug-related, patient-related, And quality of life related to these three aspects. Conclusion: The pharmacist-led review of medication has no significant effect on improving the quality of life of patients, reducing the hospitalization rate and mortality, and has a good effect on streamlining the number of drugs, determining the theme of pharmacy services, and improving the benefits of drug treatment in patients.