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目的:进一步认识肠道原发性NHL的临床病理学特征。方法:收集肠道淋巴瘤20例,应用多组织石蜡切片技术,免疫组化S-P方法标记观察。结果:20例中男16例,女4例,年龄12~78岁,平均53岁。临床表现以腹胀、下腹疼痛,腹内可触及包块为主要症状。发生部位回盲部8例、小肠7例、结肠4例、直肠1例。形态表现MALT型淋巴瘤19例,其中弥漫性大B细胞淋巴瘤伴MALT型淋巴瘤表现6例;肠病型间变性T细胞淋巴瘤1例。结论:肠道淋巴瘤以MALT型最多见,临床上很难与肠癌鉴别,早期诊断依赖肠镜活检,预后与规范化治疗有关。
Objective: To further understand the clinicopathological features of primary intestinal NHL. Methods: 20 cases of intestinal lymphoma were collected. The paraffin sections of multiple tissues were collected and labeled by immunohistochemical S-P method. Results: 20 males and 16 females, 4 females, aged 12 to 78 years, mean 53 years. Clinical manifestations of abdominal distension, abdominal pain, intra-abdominal palpable mass as the main symptoms. There were 8 cases of ileocecal site, 7 cases of small intestine, 4 cases of colon and 1 case of rectum. MALT lymphoma in 19 cases showed morphological features, including diffuse large B cell lymphoma with MALT lymphoma in 6 cases; enteric degeneration T cell lymphoma in 1 case. Conclusions: The most common type of intestinal lymphoma is MALT type, which is difficult to distinguish from intestinal cancer in clinic. Early diagnosis depends on colonoscopy biopsy, prognosis and standardization therapy.