正常细胞和瘤细胞生长的部位差异是实验变异性的主要来源。大量的研究证明:皮下和皮内接种的小鼠肿瘤在宿主小鼠的胸侧和胸背部生长最快;腰部背侧生长最慢,而腹中部的生长速度居中。此外,接种针直接刺入腹膜腔头端与尾端相比,来自固体肿瘤的细胞的死亡率要高一倍。 Site differences in the growth of normal cells and tumor cells are the main source of experimental variability. Numerous studies have shown that subcutaneously and intradermally inoculated mouse tumors grow fastest on the thoracic and thoracic and dorsal sides of the host mice, slowest on the dorsal side of the waist, and moderately on the midbrain. In addition, the inoculation needle directly pierces the peritoneal cavity head and tail compared to cells from solid tumors, the mortality rate to be doubled.