若干年前,已提出生长激素(GH)促进胰岛素依赖性糖尿病的微血管病变,这些人具有明显的GH增高。即使在门诊采用“泵治疗”的糖尿病人中也证明了糖尿病人GH水平是增高的。而且,GH可促发临床上明显的血糖升高。 GH分泌能被毒蕈碱胆碱能阻断剂所抑制,这种阻断剂不能通过血脑屏障。在糖尿病患者应用抗胆碱能制剂的试验中得到证实,溴甲东莨菪碱溴化物能阻滞应激和睡眠时GH分泌,并且证明溴化丙 Several years ago, microvascular lesions of insulin-dependent diabetes mellitus have been proposed with growth hormone (GH), which have a marked increase in GH. Even in patients with “pump-treated” diabetes at the outpatient setting, GH levels in diabetics have been shown to be elevated. Moreover, GH can promote clinically significant elevated blood sugar. GH secretion can be inhibited by muscarinic cholinergic blockers, which block the blood-brain barrier. In trials of anticholinergic agents in diabetic patients, it was shown that scopolamine bromide blocks GH secretion during stress and sleep, and that bromopropane