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目的观察血液灌流(HP)治疗急性有机磷中毒(AOPP)的疗效。方法对2008年3月-2010年3月收治的急性中重症有机磷中毒患者46例随机分为两组。其中血液灌流组24例为治疗组,常规治疗组22例为对照组。对照组给予洗胃、利尿、阿托品解毒,解磷定恢复胆碱酯酶活性等对症治疗。治疗组在常规治疗的基础上加用血液灌流治疗。比较两组疗效。结果治疗组意识恢复时间、住院天数低于对照组(P<0.05),阿托品总量明显减少(P<0.05),治愈率高于对照组(P<0.05),病死率低于对照组(P<0.05)。结论血液灌流可缩短昏迷时间,减少并发症,提高治愈率,减少医护人员工作量,缩短住院日,降低病死率,且操作简单、安全、可靠,是抢救急性中重症有机磷中毒患者有效方法之一。
Objective To observe the effect of hemoperfusion (HP) on acute organophosphorus poisoning (AOPP). Methods 46 cases of acute severe organophosphate poisoning admitted from March 2008 to March 2010 were randomly divided into two groups. Among them, 24 cases in hemoperfusion group were treated group, while 22 cases in routine treatment group were control group. The control group was given gastric lavage, diuretic, atropine detoxification, phosphorus-free recovery of cholinesterase activity and symptomatic treatment. The treatment group was treated with hemoperfusion on the basis of routine treatment. Compare the two groups curative effect. Results The recovery time and length of hospital stay in the treatment group were lower than those in the control group (P <0.05), and the total amount of atropine decreased significantly (P <0.05). The cure rate was higher in the treatment group than in the control group (P <0.05) <0.05). Conclusion Hemoperfusion can shorten the coma time, reduce complications, improve the cure rate, reduce the workload of medical staff, shorten the hospital stay, reduce mortality, and simple, safe and reliable, is an effective method to rescue patients with acute severe organophosphate poisoning one.