论文部分内容阅读
白细胞介素(IL_s)是一组重要的免疫活性淋巴因子:在机体免疫应答及调节中发挥多种生物效应。现已公认的 IL_s 包括 IL-1～6。随着基因工程技术的飞速发展,各类 IL_s 的 cDNA 相继克隆。重组的纯品 IL,为进一步探讨 IL_s 在体内的效应及机制开辟了道路。短短几年,各类 IL_s 的相应受体均已得到征实,并对其特性有了初步了解。IL_s 受体的研究一方面扩大了人类对免疫活性细胞因子作用机制及信号传递的认识,另一方面也推动了其它内分泌激素、神经肽类递质和细胞因子受体的研究发展。本文拟着重论述 IL_s 受体的研究方法,各类 IL_s 受体的生物学性质、细胞分布特征以及功能意义等,并对 IL_s 和 IL_s 受体共同组成的白细胞介素系统做一简介.
Interleukins (ILs) are a group of important immunologically active lymphokines that exert a variety of biological effects in the body’s immune response and regulation. It is now recognized that IL_s includes IL-1 ~ 6. With the rapid development of genetic engineering technology, various types of IL_s cDNA have been cloned. Recombinant pure IL, to further explore the IL_s in vivo effects and mechanisms opened the way. In just a few years, the corresponding receptors for all types of IL_s have been validated and their characteristics have been initially understood. On the one hand, the research of IL-2 receptor has widened human cognition on the mechanism of action of immunocompetent cytokines and signaling, and on the other hand, it has also promoted the research and development of other endocrine hormones, neuropeptide neurotransmitters and cytokine receptors. This article will focus on ILs receptor research methods, the biological properties of various types of IL_s receptors, cell distribution characteristics and functional significance, and IL_s and IL_s receptors together constitute a brief introduction of interleukin system.