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目的探讨类风湿性关节炎(RA)患者血清白介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)的水平变化及意义。方法选取2014年10月-2016年12月本院收治的54例RA患者为研究组,其中活动期30例,非活动期24例;另选取同期健康体检者50例为对照组。抽取两组空腹静脉血5 ml,采用免疫比浊法检测IL-33、TNF-α、CRP水平,对比两组间及研究组RA不同分期IL-33、TNF-α、CRP水平的差异。结果研究组IL-33、TNF-α、CRP水平均高于对照组,差异有统计学意义(均P<0.05);活动期患者IL-33、TNF-α、CRP水平均高于对照组,差异有统计学意义(均P<0.05);RA患者血清中IL-33、TNF-α、CRP水平之间均呈显著正相关(均P<0.05)。结论 IL-33、TNF-α、CRP在RA病情的发生发展中具有重要作用,三者水平变化对RA病理机制探讨、病情监测与评估以及治疗方案制定方面具有较高临床意义。
Objective To investigate the changes of serum interleukin-33 (IL-33), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in patients with rheumatoid arthritis (RA) Methods From October 2014 to December 2016, 54 RA patients admitted to our hospital were selected as the research group, including 30 active cases and 24 inactive patients. Another 50 healthy subjects were selected as the control group. The levels of IL-33, TNF-α and CRP in two groups of fasting venous blood samples were determined. The levels of IL-33, TNF-α and CRP in different stages of RA were compared between the two groups. Results The levels of IL-33, TNF-α and CRP in the study group were significantly higher than those in the control group (all P <0.05). The levels of IL-33, TNF-α and CRP in the active group were higher than those in the control group (All P <0.05). The levels of IL-33, TNF-α and CRP in RA patients were positively correlated with each other (all P <0.05). Conclusion The levels of IL-33, TNF-α and CRP play an important role in the pathogenesis of RA. The changes of the three levels are of great clinical significance in the pathogenesis of RA, the monitoring and evaluation of the disease, and the formulation of the treatment regimen.