目的通过1例Ph阳性急性淋巴细胞白血病患者接受伊马替尼治疗后出现全身多发静脉血栓的病例分析和文献复习,进一步探讨该药物治疗的安全性。方法对1例伊马替尼治疗Ph阳性急性淋巴细胞白血病患者的临床资料进行分析并结合文献复习,使临床医生在今后治疗中可能出现的不良反应引起重视。结果 1例确诊为Ph阳性急性淋巴细胞白血病的患者接受伊马替尼治疗后出现全身多发静脉血栓。结论伊马替尼治疗Ph阳性急性淋巴细胞白血病时可能出现全身多发静脉血栓的不良反应。 OBJECTIVE: To investigate the safety and efficacy of imatinib therapy in patients with Ph-positive acute lymphoblastic leukemia after systemic therapy and literature review. Methods The clinical data of 1 patient with Ph-positive acute lymphoblastic leukemia treated with imatinib were analyzed and reviewed in the literature, which made clinicians pay more attention to the possible adverse reactions in the future treatment. Results One patient diagnosed with Ph-positive acute lymphoblastic leukemia had systemic multiple venous thrombosis after treatment with imatinib. Conclusion Imatinib treatment of Ph-positive acute lymphoblastic leukemia may appear systemic multiple venous thrombosis adverse reactions.