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目的:观察愈癫汤对MK-801致谷氨酸功能低下精神分裂症模型大鼠认知与学习记忆功能的影响。方法:SD雄性成年大鼠48只,随机分为空白组、模型组、利培酮组及愈癫汤组。其中模型组、利培酮组及愈癫汤组应用MK-801腹腔注射造模,空白组应用0.9%Na Cl溶液行相同方法腹腔注射,连续14 d。造模结束,于第15天起,利培酮组给予0.036 g/L利培酮悬浊液灌胃,愈癫汤组给予浓度0.92 g/ml愈癫汤水煎剂灌胃,空白组、模型组给予相应体积蒸馏水灌胃,连续14 d。应用Morris水迷宫进行行为学评价,观察并比较各组受试大鼠认知及学习记忆能力。结果:学习第4天、第5天,模型组大鼠逃避潜伏期较空白组明显延长(P<0.05,P<0.01);与模型组比较,愈癫汤组大鼠逃避潜伏期时间明显缩短(P<0.05)。愈癫汤组大鼠各时间点逃避潜伏期呈下降趋势,在学习第2天起即呈现显著下降趋势(P<0.05,P<0.01)。模型组大鼠穿越安全平台次数、中央活动路程比及中央活动时间比较空白组明显降低(P<0.01);与模型组比较,愈癫汤组大鼠穿越安全平台的次数明显增加,中央活动路程比及中央活动时间比均明显升高(P<0.05,P<0.01)。结论:愈癫汤能够改善精神分裂症模型大鼠认知及学习记忆功能,并缓解其焦虑、恐惧症状。
Objective: To observe the effect of Yuyientang Decoction on cognition and learning and memory of MK-801-induced glutamate-induced schizophrenia in rats. Methods: Forty-eight SD male adult rats were randomly divided into blank group, model group, risperidone group and Yuyientang group. The model group, risperidone group and Yuyentang group were injected intraperitoneally with MK-801. The blank group was injected intraperitoneally with 0.9% NaCl solution for 14 days. At the end of the 15th day, the rats in risperidone group were given orally with 0.036 g / L risperidone orally. The more epileptic soup was given orally with the concentration of 0.92 g / ml, Group given the corresponding volume of distilled water, continuous 14 d. The Morris water maze was used to conduct behavioral evaluation, and the cognition and learning and memory abilities of the rats in each group were observed and compared. Results: Compared with the model group, the escape latency of rats in the model group was significantly longer than that of the blank group (P <0.05, P <0.01) on the 4th and 5th day after learning <0.05). The escape latency of Yuyin Tang group decreased gradually at each time point and decreased significantly from the second day of learning (P <0.05, P <0.01). Compared with the model group, the number of rats passing through the safety platform in the model group was significantly increased compared with the control group (P <0.01). The number of passing through the safety platform in the model group was significantly higher than that in the blank control group Than the central activity time were significantly higher (P <0.05, P <0.01). Conclusion: Epilepsy can improve cognition and learning and memory of schizophrenia rats and relieve anxiety and phobic symptoms.