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[目的]探讨汉族与朝鲜族高尿酸血症患病水平及其与多种代谢异常的关系。[方法]对2006年8月～2008年8月收集的4771名不同民族农村居民血样本进行尿酸及代谢相关指标检测。[结果]高尿酸血症粗患病率(12.0%,8.6%)及其标化率(10.8%,9.6%)汉族女性均高于朝鲜族女性(均P﹤0.01)。男性高尿酸血症患病率高于女性(均P﹤0.05)。汉族除了高血糖的检出率各尿酸组间差异无统计学意义外,肥胖、高血压、高TG、高TC、低高密度脂蛋白血症各尿酸组间差异均有统计学意义(均P﹤0.01)。朝鲜族各尿酸水平组代谢性疾病检出率差异均有统计学意义(均P﹤0.05)。汉族和朝鲜族,随着尿酸水平的升高呈现明显的多种代谢异常集结现象(均P﹤0.01);而且,随着代谢综合征组分数的增加,高尿酸血症患病率增加(均P﹤0.01)。多因素Logistic回归分析结果发现,调整性别、民族及年龄,整体型肥胖、腹部肥胖、高血压、高TC、高TG和MS与高尿酸血症患病密切相关。[结论]该地区高尿酸血症患病率出现明显的民族(女性)及性别差异。整体型肥胖、腹部肥胖、高血压、高TC、高TG和代谢综合征与该地区高尿酸血症患病密切相关。
[Objective] To investigate the prevalence of hyperuricemia in Han and Korean and its relationship with various metabolic abnormalities. [Method] Blood samples of 4771 rural residents collected from August 2006 to August 2008 were tested for uric acid and its metabolites. [Results] The crude prevalence of hyperuricemia (12.0%, 8.6%) and its standardized rate (10.8%, 9.6%) were higher in Han women than in Korean women (all P <0.01). The prevalence of hyperuricemia in males was higher than that in females (all P <0.05). In addition to the detection rate of hyperglycemia in Han Han people between the uric acid group was no significant difference, the obesity, hypertension, high TG, high TC, low HDL uric acid group differences were statistically significant (P <0.01). There were significant differences in the detection rate of metabolic diseases between Korean and UA group (all P <0.05). Han and Korean nationality, with the increase of uric acid level, there was obvious accumulation of various metabolic abnormalities (both P <0.01); furthermore, the prevalence of hyperuricemia increased with the increase of metabolic syndrome P <0.01). Multivariate logistic regression analysis found that gender, ethnicity and age, overall obesity, abdominal obesity, hypertension, high TC, high TG and MS were closely related to the prevalence of hyperuricemia. [Conclusion] The prevalence of hyperuricemia in this area shows obvious ethnic (female) and gender differences. Overall obesity, abdominal obesity, high blood pressure, high TC, high TG and metabolic syndrome are closely related to the prevalence of hyperuricemia in the area.