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1.什么是免疫球蛋白(Ig)的Fc部分?IgG的Fc部分有何功能? 答:Ig分子重链相当于CH2至CH3(IgM及IgE为CH2至CH4)功能区的部分,称为Ig的Fc部分。其功能:①激活补体经典途径;②通过胎盘;③经活化(Fab部分与抗原结合)后,能与吞噬细胞上的相应受体结合促进吞噬;与K细胞或巨噬细胞的Fc受体结合,引起抗体依赖性细胞介导细胞毒作用(ADCC);④主要决定Ig作为免疫原的特异性。
1. What is the Fc portion of an immunoglobulin (Ig)? What is the function of the Fc portion of an IgG? A: The heavy chain of an Ig molecule corresponds to the portion of the CH2 to CH3 (IgM and IgE CH2 to CH4) functional domains called Ig Of the Fc portion. Its function: (1) activation of the classical pathway of complement; (2) through the placenta; (3) after activation (Fab part of the antigen binding), with phagocytes on the appropriate receptor to promote phagocytosis; and K cells or macrophages Fc receptor binding , Resulting in antibody-dependent cell-mediated cytotoxicity (ADCC); ④ mainly determine the specificity of Ig as an immunogen.