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目的探讨肥胖/超重儿童与非酒精性脂肪性肝病(NAFLD)发病的相关因素,以期减少NAFLD的发生。方法随机选择2012年1月~2015年11月儿童保健门诊正常查体3~10岁肥胖/超重儿童35例,空腹采血查肝功、血糖、血脂、体质指数(BMI)、肝胆彩超等,采集平素生活习惯信息,并与35例正常儿童结果进行统计学分析。结果两组间肥胖家族史比较差异非常显著,糖尿病家族史、血脂、血糖异常率比较差异均无显著性,而两组间谷丙转氨酶(ALT)异常率、患儿腹围比较差异有统计学意义(P<0.05)。结论儿童肥胖/超重与遗传因素有关,不良饮食习惯为其诱因之一,与静态生活方式相关性不大;非侵入性诊断手段为早期诊断NAFLD提供依据,ALT检测可作为筛查指标之一。
Objective To investigate the related factors of the incidence of NAFLD in obese / overweight children and to reduce the incidence of NAFLD. Methods A total of 35 obese and overweight children aged 3 ~ 10 years were randomly selected from January 2012 to November 2015 in children’s health clinics. Fasting blood was used to check liver function, blood glucose, blood lipid, body mass index (BMI) General lifestyle information, and with 35 normal children results for statistical analysis. Results There were significant differences in obesity family history between the two groups. There was no significant difference in family history of diabetes, blood lipids and blood glucose abnormalities between the two groups. There was significant difference between the two groups in the abnormal rate of alanine aminotransferase (ALT) and abdominal circumference Significance (P <0.05). Conclusion Childhood obesity / overweight is related to genetic factors. Poor dietary habits are one of the inducing factors and have little correlation with static lifestyles. Noninvasive diagnostic methods provide the basis for early diagnosis of NAFLD. ALT can be used as one of the screening indicators.