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高渗盐水是指浓度高于9 g/L的氯化钠溶液,研究证实高渗盐水用于失血性休克及脑外伤患者的有效性主要在于其扩容作用及免疫调节效应。高渗盐水的免疫调节效应及其机制仍在探讨阶段,高渗盐水的免疫调节效应在颅脑损伤、脑出血和失血性休克等各种病理状态的改善中发挥着重要作用,主要是通过调节单核细胞、中性粒细胞等免疫细胞及免疫活性物质的分泌实现的。免疫调节的主要机制可能是高渗盐水影响免疫细胞表面分子的表达和某些活性物质的分泌。我们总结了高渗盐水的免疫调节效应及机制。
Hypertonic saline refers to the concentration of sodium chloride solution higher than 9 g / L, the study confirmed that the effectiveness of hypertonic saline for hemorrhagic shock and traumatic brain injury mainly lies in its expansion and immunomodulatory effects. Immunomodulatory effects and mechanisms of hypertonic saline are still under discussion. The immunomodulatory effect of hypertonic saline plays an important role in the improvement of various pathological conditions such as brain injury, cerebral hemorrhage and hemorrhagic shock, mainly through the regulation Monocytes, neutrophils and other immune cells and the secretion of immune active substances to achieve. The main mechanism of immune regulation may be hypertonic saline affect the expression of immune cell surface molecules and the secretion of certain active substances. We summarized the immunomodulatory effects and mechanisms of hypertonic saline.