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作者报告用重组α_2干扰素(rIFN-α_(2a))治疗两组慢性乙型肝炎患儿的结果。第1组:将24例2~23岁的西班牙慢性乙型肝炎患者随机分为对照组(12人)和治疗组。治疗组肌肉注射10MU/m~2rIFN-α_(2a),每周3次,连续3个月。治疗前所有患者均经组织学诊断为慢性活动性肝炎,HBsAg、HBeAg和HBV-DNA阳性至少达6个月。治疗后,3例患者的HBV-DNA转阴。对这4例患者随访12个月,HBV-DNA保持阴性。而对照组在研究后头6个月未见HBV-DNA阴转,但2例患者在第9个月时HBV-DNA阴
The authors report the results of treatment of children with chronic hepatitis B with recombinant interferon alpha (rIFN-α_ (2a)). Group 1: 24 patients aged 2 to 23 years with chronic hepatitis B were randomly divided into control group (12) and treatment group. Treatment group intramuscular injection of 10MU / m ~ 2rIFN-α_ (2a), 3 times a week for 3 consecutive months. All patients were histologically diagnosed as chronic active hepatitis before treatment, with HBsAg, HBeAg and HBV DNA positive for at least 6 months. After treatment, HBV-DNA in 3 patients turned negative. The 4 patients were followed up for 12 months, HBV-DNA remained negative. The control group in the first 6 months after the study did not see HBV-DNA overcast, but 2 patients at the 9th month when HBV-DNA negative