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在新近蛋白质组学的发展中,对疾病蛋白质组的综合和深入研究已成为重要议题。已有研究报道了在包括肺癌在内的不同疾病中发现的一些生物标志物,有一些在肺癌诊断和预测中有潜在价值。然而,它们很少作为器官特异性生物标志物以充分比较不同肿瘤类别的模型。本文评价了最近发表的一项在不同基因工程小鼠模型中进行比较蛋白质组的研究,并阐明已发现标志物在人肺癌诊断中的有效性及应用。
In the recent development of proteomics, comprehensive and in-depth studies of the disease proteome have become important topics. Some studies have reported some biomarkers found in different diseases including lung cancer, and some have potential value in the diagnosis and prognosis of lung cancer. However, they are seldom used as organ-specific biomarkers to adequately compare models of different tumor types. This article evaluates a recently published study comparing proteomics in different genetically engineered mouse models and elucidates the usefulness and utility of the identified markers in the diagnosis of human lung cancer.