目的探讨慢性非特异性溃疡性结肠炎的临床特点和治疗效果。方法选择我院2008年7月至2012年2月慢性非特异性溃疡性结肠炎患者26例,分析其临床症状和内镜下表现。本组患者根据患者病变严重程度、活动度和病变范围实施临床治疗。轻中度患者给予5-氨基水杨酸类药物美沙拉嗪治疗;重度患者给予波尼松,或者静脉滴注氢化可的松;合并有肠道感染的可给予喹诺酮类、替硝唑等抗感染治疗。结果本组患者经治疗后临床症状和体征均有不同程度缓解,其中1例患者服用柳氮磺胺吡啶后出现皮疹,换药后皮疹好转至消失;1例患者在治疗过程中合并消化道出血而转至外科手术治疗。本组患者中痊愈19例,有效6例,无效1例。总有效效率为96.1%。结论慢性非特异性溃疡性结肠炎主要是消化系统临床表现,内镜和病理组织学检查有助于其临床诊断,以5-氨基水杨酸类制剂同时辅以糖皮质激素类药物为主,根据患者具体情况给予个体化及综合性治疗有助于改善患者预后。 Objective To investigate the clinical features and therapeutic effects of chronic nonspecific ulcerative colitis. Methods Twenty-six patients with chronic nonspecific ulcerative colitis in our hospital from July 2008 to February 2012 were selected and their clinical symptoms and endoscopic findings were analyzed. This group of patients according to the severity of the patient’s disease, activity and extent of disease implementation of clinical treatment. Mild to moderate patients given 5 - aminosalicylate mesalazine treatment; severe patients given prednisone, or intravenous infusion of hydrocortisone; with intestinal infection can be given quinolones, tinidazole and other anti- Infection treatment. Results After treatment, the clinical symptoms and signs of the patients were relieved to varying degrees. One patient took a rash after taking sulfasalazine and the rash improved to disappear after dressing change. One patient had gastrointestinal bleeding during the course of treatment Go to Surgical Treatment. In this group of patients recovered in 19 cases, effective in 6 cases, 1 case of ineffective. The total effective efficiency was 96.1%. Conclusion Chronic nonspecific ulcerative colitis is mainly the clinical manifestations of digestive system. Endoscopy and histopathological examination are helpful to its clinical diagnosis. The main 5-aminosalicylic acid supplemented with glucocorticoid drugs, according to Patients with individual circumstances and comprehensive treatment can help to improve patient prognosis.