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洋地黄应用于临床已有200多年的历史,至今仍被公认为一种可靠的增强心肌收缩力的正性收缩能药物。但是,洋地黄治疗宽度狭窄,治疗量约为中毒量的2/3,而毒性作用开始时该剂量已达到最小致死量的40％。又有许多因素影响机体的敏感性,对药物反应缺乏可靠的估计指标。由于个体差异,不易找到适当的疗效标准。早期中毒迹象难于发现,合理的剂量较难掌握。有人认为,传统的洋地黄化法(“饱和量
Digitalis has been used clinically for more than 200 years and is still regarded as a reliable positive contractile drug for enhancing myocardial contractility. However, digitalis has a narrow treatment width of about two-thirds of the toxic dose and the toxic dose initially reaches 40% of the minimum lethal dose. There are many other factors that affect the body’s sensitivity and lack of reliable estimates of drug response. Due to individual differences, not easy to find the appropriate standard of efficacy. Early signs of poisoning difficult to find, a reasonable dose difficult to grasp. Some people think that the traditional digitalis method ("saturation