论文部分内容阅读
二膦酸盐(Bisphosphonates,BPs)作为一种强效骨吸收作用抑制剂已经用于临床30多年,广泛用于控制与骨更新改变相关的疾病。近年来发现,临床长期应用二膦酸盐类药物可导致颌骨骨坏死。对于二膦酸盐颌骨骨坏死的治疗,学术界观点不一,包括保守治疗、手术刮治、颌骨切除(重建或不重建)。本文介绍1例采用血管化腓骨瓣修复二膦酸盐颌骨骨坏死造成的下颌骨缺损,效果满意。
Bisphosphonates (BPs) have been used clinically for over 30 years as a potent inhibitor of bone resorption and are widely used to control diseases associated with altered bone turnover. In recent years, found that clinical long-term use of bisphosphonates can lead to jaw osteonecrosis. For the treatment of bisphosphonate jaw osteonecrosis, the academic view varies, including conservative treatment, surgical curettage, jaw resection (reconstruction or non reconstruction). This article describes a case of vascularized fibula flap repair of bisphosphonate jaw osteonecrosis caused by mandibular defects, with satisfactory results.