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目的:探讨糖耐量低减(IGT)患者的红细胞胰岛素酶活性(EIA)与胰岛素抵抗(IR)的关系。方法:用放射酶分析法检测50例IGT患者和20例正常对照的EIA及相关指标,并计算稳态模型胰岛素抵抗指数(HOMA-IR)以评价机体的胰岛素敏感性。结果:IGT患者的EIA、空腹血清胰岛素(FINS)和HOMA-IR指数显著高于正常对照(P<0.01),伴空腹血糖异常的IGT患者与空腹血糖正常的IGT患者相比,前者的EIA、FINS、HOMA-IR显著高于后者(P<0.01或0.05)。直线回归分析表明,IGT患者的EIA与FINS、HbA1c和HOMA-IR指数呈显著正相关(P<0.01或0.05)。结论:IGT患者的红细胞胰岛素降解速度显著高于正常,并与其IR的发生、发展有关。
Objective: To investigate the relationship between erythrocyte insulin activity (EIA) and insulin resistance (IR) in patients with impaired glucose tolerance (IGT). Methods: The EIA and related indexes of 50 IGT patients and 20 normal controls were detected by radioimmunoassay. The homeostasis model insulin resistance index (HOMA-IR) was calculated to evaluate the body’s insulin sensitivity. Results: The levels of EIA, FINS and HOMA-IR in patients with IGT were significantly higher than those in controls (P <0.01). Compared with patients with IGT with fasting plasma glucose and IGT, FINS, HOMA-IR were significantly higher than the latter (P <0.01 or 0.05). Linear regression analysis showed that the IGT patients EIA and FINS, HbA1c and HOMA-IR index was significantly correlated (P <0.01 or 0.05). CONCLUSION: The rate of erythrocyte insulin degradation in patients with IGT is significantly higher than that of normal, and related to the occurrence and development of IR.