胆固醇对动脉粥样硬化等心脑血管疾病的发生发展影响极大,在中枢神经系统的发育和功能活动中也起着关键性作用[1,2]。神经系统的顺利运转有赖于神经细胞间的联系,而这种联系是通过突触来完成的。Pfieger等发现体外培养中突触产生、发育、成熟和维持有赖于星形胶质细胞(AS)释放 Cholesterol has a great influence on the occurrence and development of cardiovascular and cerebrovascular diseases such as atherosclerosis and plays a key role in the development and functional activities of the central nervous system [1,2]. The smooth functioning of the nervous system depends on the connection between nerve cells, and this connection is done through the synapses. Pfieger et al found that synaptogenesis, development, maturation and maintenance in vitro depend on the release of astrocytes (AS)