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目的:分析在脑外伤术后脑脊液漏伴颅内感染焦虑抑郁症治疗中有效的治疗方法及临床治疗效果。方法:选择2013年1月至2016年12月重庆市石柱县人民医院收治的脑外伤术后脑脊液漏伴颅内感染焦虑抑郁症66例进行分析,采用随机数字法分为对照组和观察组,两组患者首先予以常规治疗,即予以患者抗抑郁药物、脑循环改善药物及扩血管药物等,在此基础上观察组患者予以腰大池置管持续引流、稀释头孢曲松经引流管进行鞘内注射;而对照组患者予以常规反复腰穿及稀释头孢曲松经引流管进行鞘内注射,观察结束后对比分析疗效。结果:治疗后与对照组相较,观察组患者的临床症状缓解时间明显较短、感染控制时间明显较短、感染控制率明显较高、脑脊液漏治愈率明显较高、重残率明显较低、死亡率明显较低,差异具有统计学意义(P<0.05);而治疗前两组患者的焦虑评分和抑郁评分比较,差异无统计学意义(P>0.05),而治疗后,观察组患者的焦虑评分和抑郁评分明显优于对照组,差异具有统计学意义(P<0.05)。结论:在脑外伤术后脑脊液漏伴颅内感染焦虑抑郁症治疗中予以腰大池置管持续引流与鞘内注射稀释头孢曲松经引流管联合治疗效果明显。
Objective: To analyze the effective treatment and clinical curative effect of treating cerebrospinal fluid leakage with intracranial infection and anxiety and depression after traumatic brain injury. Methods: From January 2013 to December 2016, 66 cases of cerebrospinal fluid leakage with intracranial infection and anxiety and depression after traumatic brain injury were treated in Shizhu County People’s Hospital of Chongqing Municipality. The patients were divided into control group and observation group by random number method. The two groups of patients were treated first, that is, patients with antidepressant drugs, cerebral circulation to improve drugs and vasodilator drugs, etc., on the basis of observation group patients were lumbar cistern catheter for sustained drainage, dilution of ceftriaxone drainage tube for intrathecal While the control group patients were routinely repeated lumbar puncture and dilution of ceftriaxone drainage tube for intrathecal injection, after the end of the comparative analysis of efficacy. Results: Compared with the control group, the patients in the observation group had significantly shorter clinical symptoms, shorter infection control time, significantly higher infection control rate, significantly higher cure rate of cerebrospinal fluid leakage and significantly lower severe disability rate , The mortality rate was significantly lower, the difference was statistically significant (P <0.05); while the anxiety score and depression score of the two groups before treatment, the difference was not statistically significant (P> 0.05), and after treatment, the observation group patients Anxiety score and depression score were significantly better than the control group, the difference was statistically significant (P <0.05). CONCLUSION: Continuous drainage of lumbar cistern and intrathecal injection of ceftriaxone via drainage tube with combined treatment of cerebrospinal fluid leakage and intracranial infection with anxiety and depression after traumatic brain injury are effective.