在麻醉动物实验中,经过神经节阻断剂或可卡因的增敏,可见利血平静脉注射后出现血压升高时相。本实验室在不麻醉的正常大白鼠上,连续几天注射利血平,亦观察到这种升压时相,并根据血压曲线与肾上腺内兒茶酚胺含量曲线间的相互关系,推测此升压作用主要由于利血平释放肾上腺中多量兒茶酚胺所致。为此采用去肾上腺动物实验,进一步探讨利血平升压时相的产生机制。 In anaesthetized animal experiments, after sensitization of ganglionic blocking agents or cocaine, the phase of elevated blood pressure appears after intravenous injection of reserpine. In this laboratory, reserpine was injected for several consecutive days on normal non-anesthetized rats. This step-up phase was also observed. Based on the correlation between the blood pressure curve and the content curve of adrenal catecholamines, the effect of pressure increase was estimated. Mainly due to the release of a large amount of catecholamines in the adrenal gland caused by reserpine. For this reason, denervation animal experiments were used to further investigate the mechanism of reserpine-boosting phase.