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目的:建立紫外法测定氨茶碱和加替沙星的含量,并考察两种药物在5％葡萄糖注射液中的配伍稳定性。方法:在室温条件下,用紫外分光光度法分别测定氨茶碱和加替沙星在5％葡萄糖注射液中配伍后24 h内的含量变化情况;并观察其外观和pH变化。结果:氨茶碱和加替沙星平均回收率分别为100．24％,99．77％;RSD分别为0．65％,0．86％。常温放置24 h 内样品pH值及含量均无明显变化,但颜色变浅。结论:氨茶碱与加替沙星葡萄糖注射液配伍使用可不考虑含量变化。
OBJECTIVE: To establish a UV method for the determination of aminophylline and gatifloxacin, and investigate the compatibility of two drugs in 5% glucose injection. Methods: The contents of aminophylline and gatifloxacin in 5% dextrose injection were determined by UV spectrophotometry at room temperature within 24 h. The changes of appearance and pH were also observed. Results: The average recoveries of aminophylline and gatifloxacin were 100.24% and 99.77%, respectively. The RSDs were 0.65% and 0.86% respectively. No significant change in pH value and content of samples within 24 h at room temperature, but lighter in color. Conclusion: Aminophylline and gatifloxacin dextrose injection compatibility can be used without considering the content changes.