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[Objective] To research the anti-inflammatory mechanism of HERBA COMMELINAE. [Methods] Contents of MDA,PGE2,TNF-α and IL-1β were detected in chest exudate of rats,as well as the contents of NO,PGE2,TNF-α,IL-1β and MDA in lung tissues. The anti-inflammatory mechanism was discussed. [Results] Compared with 5% Tween-80 group,HERBA COMMELINAE ethanol crude extracts group and water soluble part group reduced the MDA,PGE2,TNF-α and IL-1β contents in inflammatory exudate of rats chest( P < 0. 01),and restricted the increase of NO,MDA,PGE2,TNF-α and IL-1β contents of lung tissues( P < 0. 01). [Conclusions] The anti-inflammatory mechanism of HERBA COMMELINAE might be related to the restriction of antioxidation and inflammatory mediator generation.
[Methods] Contents of MDA, PGE2, TNF-α and IL-1β were detected in chest exudate of rats, well as the contents of NO, PGE2, TNF- The anti-inflammatory mechanism was discussed. [Results] Compared with 5% Tween-80 group, HERBA COMMELINAE ethanol crude extracts group and water soluble part group reduced the MDA, PGE2, TNF- α and IL-1β contents in inflammatory exudate of rats chest (P <0.01), and restricted the increase of NO, MDA, PGE2, TNF-α and IL-1β contents of lung tissues (P <0.01). [Conclusions] The anti-inflammatory mechanism of HERBA COMMELINAE might be related to the restriction of antioxidant and inflammatory mediator generation.