由血浆脂蛋白的合成、加工或分解代谢异常引起的脂蛋白代谢紊乱大多与遗传因素有关。利用逆转录病毒、腺病毒等载体,通过体细胞基因转移方法导入与脂质代谢及转运相关的基因,对由遗传因素引起的脂蛋白代谢紊乱达到有效的调节,并对阻止或逆转动脉粥样硬化的发生与发展也有重要意义。 Most of the disorders of lipoprotein metabolism caused by the synthesis, processing or catabolism of plasma lipoproteins are related to genetic factors. The use of retroviruses, adenoviruses and other vectors, gene transfer by somatic cell import and lipid metabolism and transport related genes, genetic factors caused by lipoprotein metabolism disorders to achieve effective regulation, and to prevent or reverse atherosclerosis The occurrence and development of sclerosis is also of great significance.