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目的:探讨桂皮醛解热作用及其作用机制。方法:采用酵母诱致大鼠发热模型和白细胞介素-1β(IL-1β)刺激小鼠脑微血管内皮细胞(bEnd.3)作为实验体系,采用酶联免疫法(ELISA)测定致热大鼠下丘脑组织及bEnd.3细胞上清液中前列腺素E2(PGE2)含量。结果:桂皮醛能有效抑制酵母所致大鼠发热反应,显著降低发热大鼠下丘脑PGE2含量,亦能明显抑制IL-1β刺激bEnd.3细胞PGE2的释放。结论:桂皮醛具有明显的解热作用,其解热机制可能与影响PGE2含量有关。
Objective: To investigate the antipyretic effect of cinnamaldehyde and its mechanism of action. METHODS: The rat febrile model induced by yeast and the mouse brain microvascular endothelial cells (bEnd.3) stimulated by interleukin-1β (IL-1β) were used as the experimental system. Enzyme-linked immunosorbent assay (ELISA) was used to detect the rats under heating. Prostaglandin E2 (PGE2) content in the thalamus and bEnd.3 cell supernatants. RESULTS: Cinnamon aldehyde can effectively inhibit the febrile reaction induced by yeast, significantly reduce the hypothalamus PGE2 content in febrile rats, and also significantly inhibit the release of PGE2 from bEnd.3 cells stimulated by IL-1β. Conclusion: Cinnamon aldehyde has obvious antipyretic effect, and its antipyretic mechanism may be related to the effect of PGE2 content.