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良性结直肠上皮性息肉传统上被分为两种类型:增生性息肉和腺瘤。前者具柱状吸收细胞增多形成微乳头突入腺隐窝腔中使腔面呈锯齿状及肿胀的杯状细胞的特点,被认为不具有形成肿瘤的潜能。后者具腺腔呈指状、核深染、细胞排列成多层的特点,被认为是结肠癌的先兆。除此之外,在一种息肉具有以下特征:腺腔呈锯齿状、杯状细胞发育不全、腺隐窝上部核分裂像多见,上皮细胞内可见核仁,它既具有增生性息肉的特点结构又具有腺瘤的细胞学特征,这种混合性息肉是结肠直上皮性肿瘤的一种特殊亚型,称为锯齿状腺瘤。本研究比较这三种息肉Ki—67、P_(53)及Bcl—2的表达情况。
Benign colorectal epithelial polyps have traditionally been classified into two types: hyperplastic polyps and adenomas. The former has the characteristic of columnar absorptive cells forming a micropapillary protrusion into the glandular cryptal cavity to make serrated and swollen goblet cells on the cavity surface, and is considered to have no potential for tumor formation. The latter is characterized by finger-like glands, deep staining of the nucleus, and multi-layered cells, and is considered to be a precursor to colon cancer. In addition, a polyp has the following characteristics: glandular cavity serrated, goblet cell hypoplasia, upper crypt of crypts like common, epithelial cells visible nucleoli, it has both the characteristic structure of proliferative polyps It also has the cytological characteristics of adenomas. This mixed polyp is a special subtype of colorectal cancer, called serrated adenomas. This study compared the expression of Ki-67, P53, and Bcl-2 in these three polyps.