Objective: To compare mini-probe endoscopic ultrasonography (MCUS) with computed tomography (CT) in preoperative T and N staging of esophageal cancer, and to find out the MCUS parameters to judge lymph nodes metastasis for esophageal cancer. Methods: Thirty-five patients received both MCUS and CT preoperatively, on both of which the T and N stages were determined. The accuracy, sensitivity, specificity, positive predicting value and negative predicting value were compared with the postoperative pathological results. Results: The accuracy of MCUS was 85.7% in T staging and 85.7% and 80.0% in N staging by two different methods, which were 45.7% and 74.3%, respectively, by CT. Conclusion: MCUS is better than CT in preoperative staging for esophageal cancer. The ratio of short to long axis (S/L) combined with short axis is a useful way to determine lymph nodes metastasis.