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为揭示氧化锑粉尘是否产生尘肺病变和病变的本质,用Wistar雌性大鼠研究了锑尘在肺内的作用。粉尘颗粒<3μ,其化学成份与该冶炼厂工人吸入的粉尘相同。一组经气管,另一组经腹腔注入0.5ml(50mg)粉尘悬液,二个月后观察病理变化。 肉眼可见部分动物的肺脏有少量带白色柔软的小结节。这些结节呈灰白色圆形,结节切面呈灰色糊状。有些动物的结节很小,用放大镜才能看到。肺膜下有局限性或弥漫性带灰白色的不规则病灶及多个小灰斑。病灶边缘都很清晰。 光镜下见肺内有大量形状和大小不一的黑色素沉着,还有许多小的孤立的色素斑和稀疏的黑颗粒。
To reveal whether antimony oxide dust produces the nature of pneumoconiosis and lesions, the effect of antimony dust in the lungs was studied in Wistar female rats. Dust particles <3μ, its chemical composition and the smelter workers inhaled the same dust. A group of trachea, the other group by intraperitoneal injection of 0.5ml (50mg) suspension of dust, two months after the observation of pathological changes. Visible to the naked eye some animals have a small amount of lungs with white soft nodules. These nodules are gray-white, nodular gray-like paste. Some animal nodules are small, with a magnifying glass to see. Subconjunctival limitations or diffuse gray with irregular lesions and multiple small gray spots. The edge of the lesion is very clear. Light microscope, there are a large number of lung shape and size of melanin deposition, there are many small isolated pigmented spots and sparse black particles.