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目的探讨自体造血干细胞移植(autologous hematopoietic stem cell transplantation,auto-HSCT)治疗侵袭性NK/T细胞淋巴瘤的疗效。方法对我科2005年1月16日收治的1例侵袭性NK/T细胞淋巴瘤患者的造血干细胞移植和随访资料进行回顾性分析,并复习国内外相关文献。结果患者为37岁女性,诊断结外鼻型NK/T细胞淋巴瘤,系统性,经CHOAP和ICE方案化学疗法、手术、局部放射治疗控制病情良好后,采集自体骨髓造血干细胞,行auto-HSCT,预处理方案为全身放射治疗+ECy;移植+29d造血功能即顺利重建;移植后密切随访,患者一直处于完全缓解,至今已存活67个月。结论 auto-HSCT治疗侵袭性NK/T细胞淋巴瘤疗效肯定、可靠。
Objective To investigate the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in the treatment of aggressive NK / T cell lymphoma. Methods A retrospective analysis of the hematopoietic stem cell transplantation and follow-up data of one patient with aggressive NK / T-cell lymphoma admitted to our department on January 16, 2005 was reviewed. Relevant literatures at home and abroad were reviewed. Results A 37-year-old female patient with nasal type NK / T cell lymphoma was diagnosed as systemic nasopharyngeal NK / T cell lymphoma. After controlled by CHOAP and ICE regimen, surgery and local radiotherapy, hematopoietic stem cells were collected and auto-HSCT , Pretreatment program for the whole body radiation therapy + ECy; transplantation + 29d hematopoietic function that is smooth reconstruction; close follow-up after transplantation, the patient has been in complete remission and has survived 67 months. Conclusion Auto-HSCT is effective and reliable in the treatment of aggressive NK / T cell lymphoma.