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应用酶标卵内沉淀试验(ELIOP)和血吸虫肠相关抗原间接血凝试验(GAA-IHA)检测两个不同流行程度村的血吸虫病人在吡喹酮治疗前、后的血清抗体动态.结果表明,吡喹酮治疗后3～4个月粪检阴转病人的抗体滴度均有明显下降,抗体GMRT下降较抗体阴转迅速。在钉螺基本消灭的村,ELIOP抗体滴度治后5个月即达正常范围,5～14岁组抗体水平较15岁以上年龄组下降为快;在再感染率较高的村,上述变化不明显,低年龄组治前抗体水平也较高。表明化疗后抗体水平下降速度和低年龄组抗体水平分析可作为评价防治措施效果和监测疫情的敏感指标。ELIOP和GAA-IHA的考核疗效效果的比较表明,ELIOP阴转快,可望成为比较理想的考核防治效果的血清学方法。
Serum antibody levels of schistosomiasis patients before and after praziquantel treatment in two villages of different endeavors were detected by ELIOP and GAA-IHA. The results showed that, After 3 ~ 4 months of praziquantel treatment, the antibody titers of patients in the stool examination and negative conversion were significantly decreased, and the antibody GMRT decreased more rapidly than the antibody negative. In villages where snail basically disappeared, ELIOP antibody titers reached the normal range within 5 months after treatment, and the antibody levels of 5-14-year-old group dropped faster than those over 15 years old. In the villages with high re-infection rates, the above changes were not Obviously, low-age group pre-antibody levels are higher. The results showed that the decrease of antibody level after chemotherapy and the analysis of antibody level in low age group could be used as sensitive indicators to evaluate the effect of control measures and monitor the epidemic situation. ELIOP and GAA-IHA assessment of the efficacy of the comparison showed that, ELIOP overcast fast, is expected to become the ideal test to control the effect of serological methods.