目的探讨无创双水平正压通气治疗慢性阻塞性肺病并呼吸衰竭的疗效。方法回顾分析70例患者的临床资料。结果治疗组治疗72 h后PaO2、SpO2、pH均明显升高,PaCO2、R、HR均明显下降(P均<0.01)。与对照组治疗72 h后相比,除pH、HR外其余各项指标均明显优于对照组,差异有统计学意义(P<0.01)。结论 BIPAP呼吸机能够改善COPD并Ⅱ型呼吸衰竭的通气量及肺的氧合功能,改善患者的缺氧状况和纠正CO2潴留,纠正呼吸衰竭,为基础病因治疗节省时间,使一部分患者避免使用有创机械通气。 Objective To investigate the curative effect of non-invasive bi-level positive pressure ventilation on chronic obstructive pulmonary disease and respiratory failure. Methods The clinical data of 70 patients were retrospectively analyzed. Results PaO2, SpO2 and pH were significantly increased and PaCO2, R and HR were significantly decreased in the treatment group after 72 h of treatment (all P <0.01). Compared with the control group after 72 h treatment, except for pH and HR, the rest of the indicators were significantly better than the control group, the difference was statistically significant (P <0.01). Conclusion BIPAP ventilator can improve COPD and type Ⅱ respiratory failure ventilation and lung oxygenation function, improve patients with hypoxia and correct CO2 retention, respiratory failure correction, saving time for the treatment based on the cause, so that some patients to avoid using Create mechanical ventilation.