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目的 :评价血管紧张素 受体拮抗剂——氯沙坦对糖尿病患者急性心肌梗死 (AMI)后心脏的保护作用。方法 :选择糖尿病 AMI患者 2 0例服用氯沙坦 (氯沙坦组 ) ,2 0例服用卡托普利 (对照组 ) ,应用超声心动图观察患者治疗后心脏结构及收缩功能的改变。结果 :与卡托普利治疗组类似 ,氯沙坦治疗后患者心脏腔径、容量无明显扩大 ,收缩功能无显著下降。结论 :氯沙坦能够抑制心脏重构扩大 ,对糖尿病 AMI患者心脏具有保护作用
AIM: To evaluate the protective effects of losartan, an angiotensin II receptor antagonist, on the heart of diabetic patients with acute myocardial infarction (AMI). Methods: Twenty patients with diabetes mellitus (AMI) were treated with losartan (losartan) and 20 patients with captopril (control). Echocardiography was used to observe the change of cardiac structure and systolic function. Results: Similar to captopril treatment group, losartan did not significantly increase the size and volume of cardiac cavity, and no significant decrease in systolic function. CONCLUSION: Losartan can inhibit cardiac remodeling and enlargement and has a protective effect on the heart of diabetic AMI patients