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W.P.Havens等以白喉类毒素对慢性肝脏疾患与其他疾病患者进行了抗体产生能力的比较,结果发现有慢性肝脏疾患者,其抗毒素的产量增高。我们鉴于可以引起肝脏功能障碍的疾病比较常见,为了解这些患者对于菌(疫)苗等抗原的免疫能力究竟有否受到影响,乃进行本试验,以四氯化碳破坏家兎的肝功能,再用伤寒杆菌免疫,观察其产生抗体的能力。兹将初步试验结果,报导如下:
W.P. Havens et al. used a diphtheria toxoid to compare the antibody production ability of patients with chronic liver disease and other diseases. As a result, patients with chronic liver disease were found to have increased antitoxin production. In view of the fact that the diseases that can cause liver dysfunction are relatively common, in order to understand whether the immunity of these patients to antigens such as bacteria (epidemic) seedlings has been affected, this trial was conducted to destroy the liver function of the family with carbon tetrachloride. They were then immunized with Salmonella typhi and their ability to produce antibodies was observed. The results of the preliminary test are reported as follows: