论文部分内容阅读
利用PPP-SCF-CI-DV量子化学程序拟合胆红素以及胆汁酸盐-胆红素水溶液的UV和CD谱,借以研究胆红素及其与胆汁酸盐复合物的构象性质。发现胆红素与胆汁酸盐作用时,两个双吡咯生色团的扭角由104°变成112°,仍保持形成分子内氢键的状态,其UV及CD谱两个吸收峰间隔的增宽,主要是胆红素的一侧双吡咯生色团与胆汁酸盐呈疏水性结合的原故;二羟基和三羟基胆汁酸盐所形成的二元复合物园二色谱的差别,是胆红素的对映选择性结合造成的。
The conformational properties of bilirubin and its complexes with bile salts were studied by using the PPP-SCF-CI-DV quantum chemistry program to fit the UV and CD spectra of bilirubin and bile acid-bilirubin aqueous solutions. When bilirubin was found to react with bile salts, the torsion angles of the two dipyrromethene chromophores changed from 104 ° to 112 °, maintaining the state of intramolecular hydrogen bonding. The UV and CD spectra were separated by two absorption peaks Widened, mainly bilirubin side of the bipyrrole chromophore and bile salts were hydrophobic combination of the reason; dihydroxy and trihydroxy bile salts formed by the binary complex Park dichroism difference is the gallbladder Enantioselective binding of the red pigment.