论文部分内容阅读
目的研究细菌感染对肺癌患者免疫系统的影响及其临床意义。方法17例肺癌合并感染的手术后患者及20例未合并感染的手术后患者,应用流式细胞仪定量测定其外周血中的CD4、CD8及CD56+16,并分别采用ELISA试剂盒及放射免疫分析法测定白细胞介素-2(IL-2)和肿瘤坏死因子(TNF)的含量。结果未合并感染组肺癌患者,其外周血CD4、CD4/CD8及CD56+16,IL-2和TNF含量较合并感染组显著降低(P均<0.01)。结论细菌感染对于肺癌患者免疫系统有一定的刺激作用,在某种程度上有利于抗肿瘤作用。
Objective To study the effect of bacterial infection on the immune system in patients with lung cancer and its clinical significance. Methods Seventeen patients with postoperative lung cancer complicated with infection and 20 patients without infection were enrolled in this study. CD4, CD8 and CD56 + 16 levels in peripheral blood were measured by flow cytometry. ELISA kit and radioimmunoassay The contents of interleukin-2 (IL-2) and tumor necrosis factor (TNF) were determined by analysis. Results The levels of CD4, CD4 / CD8, CD56 + 16, IL-2 and TNF in peripheral blood of patients with lung cancer without infection were significantly lower than those of patients with infection (all P <0.01). Conclusions Bacterial infection can stimulate the immune system in patients with lung cancer to a certain extent, which is beneficial to antitumor effect.