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目的:建立SD大鼠骨肉瘤模型,初步探讨DWI显示肿瘤坏死的价值。方法:将UMR-106细胞悬液接种于Sprague Dawley大鼠背部皮下,其中4周龄者16只,6周龄和8周龄者各4只。对所形成的肿瘤行MRI常规扫描、增强扫描及EPI-DWI成像并做病理对照。比较活肿瘤细胞区和坏死区的T1信号强度、T2信号强度、T1信号增加值、T1信号增强率及ADCm。结果:16只4周龄者均有肿瘤形成,6周龄者和8周龄者没有可用于实验的肿瘤形成。16只肿瘤形成者的MR扫描显示,活肿瘤细胞区和坏死区的T1、T2信号强度值之间差异无显著性意义(P>0.05)。两种组织的T1信号增加值、T1信号增强率之间差异有显著性意义(P<0.05)。两种参数确定肿瘤坏死区的敏感度为86.7%(13/15),特异度为38.5%(15/39),诊断符合率为51.9%(28/54)。活肿瘤细胞区与坏死区的ADCm之间差异有显著性意义(P<0.05),ADC值确定肿瘤坏死区的敏感度为93.3%(14/15),特异度为94.9%(37/39),诊断符合率为94.4%(51/54)。结论:EPI-DWI较传统MRI序列及增强扫描能更准确早期分辨SD大鼠骨肉瘤坏死区。
Objective: To establish SD rat osteosarcoma model and to explore the value of DWI in detecting tumor necrosis. Methods: UMR-106 cells were inoculated subcutaneously in the back of Sprague Dawley rats, including 4 rats of 4 weeks, 4 rats of 6 weeks and 8 weeks respectively. The tumors formed by conventional MRI scan, enhanced scan and EPI-DWI imaging and pathological control. Compare T1 signal intensity, T2 signal intensity, T1 signal increase value, T1 signal enhancement rate and ADCm of living tumor area and necrotic area. Results: Tumors were formed in 16 4-week-old and 6-week-old and 8-week-old without tumor formation. The MR scan of 16 tumori fi caters showed no significant difference in T1, T2 signal intensity between living tumor cells and necrotic areas (P> 0.05). There were significant differences between the two groups in T1 signal enhancement and T1 signal enhancement (P <0.05). The sensitivity and specificity of the two parameters in determining tumor necrosis were 86.7% (13/15) and 38.5% (15/39), respectively. The diagnostic coincidence rate was 51.9% (28/54). There were significant differences between the ADCm of living tumor cells and necrotic areas (P <0.05). The sensitivity of ADC value in determining tumor necrosis area was 93.3% (14/15) and the specificity was 94.9% (37/39) , The diagnostic coincidence rate was 94.4% (51/54). Conclusion: EPI-DWI can distinguish the osteosarcoma necrosis area of SD rats more accurately and accurately than the traditional MRI sequence and enhanced scan.