甲基多巴是一种广泛使用的抗高血压药物,它通过抑制抑制性T淋巴细胞功能来影响免疫调节。免疫系统的紊乱与甲基多巴某些并发症的发病机理有关,特别是Coomb氏阳性溶血性贫血和慢性活动性肝炎。一例因长期服用甲基多巴而同时引起两种并发症,当停药和给予短疗程皮质激素(强的松)时痊愈。 Methyldopa is a widely used antihypertensive drug that affects immune regulation by inhibiting suppressive T lymphocyte function. Disorders of the immune system are associated with the pathogenesis of certain complications of methyldopa, particularly Coomb’s positive hemolytic anemia and chronic active hepatitis. One case caused both complications due to long-term use of methyldopa, and recovered when the drug was discontinued and a short course of corticosteroid (prednisone) was given.