药物发现早期通常在啮齿类模型上进行在体药效实验,以优化筛选,迅速发现先导化合物,但当采用预先或同时给药方式进行时,常有过高估计新化合物疗效的可能。不利于科学决策、降低成本、时间安排及合乎伦理地使用动物。放弃预先给药方式,在模型动物上监测重要的生理参数及系统地应用简单药代-药效动力学分析可以减少假阳性结果。 Drug Discovery Early In vivo efficacy trials are usually conducted on rodent models to optimize screening for rapid detection of lead compounds but often overestimate the efficacy of new compounds when administered in advance or concurrently. Not conducive to scientific decision-making, reduce costs, scheduling and ethical use of animals. Withdrawal of premedication, monitoring of important physiological parameters in model animals, and systematic application of simple pharmacokinetic-pharmacodynamic analysis can reduce false-positive results.