论文部分内容阅读
n-3多不饱和脂肪酸为人体必需脂肪酸,其中的二十二碳六烯酸在脑组织中含量丰富,在促进脑发育方面起着重要作用,另外亦与儿童注意力缺陷-多动症、抑郁症及老年性痴呆等疾病密切相关。n-3多不饱和脂肪酸影响脑发育与功能的机制涉及多个方面,除了参与组织细胞膜的构建和通过其代谢产物发挥作用以外,还可以作用于过氧化物酶体增殖因子活化受体等转录因子,进而对多种基因的表达进行调节;这些基因涉及脂质和能量代谢、细胞黏附性、神经递质转运及信号转导等多个方面。
n-3 polyunsaturated fatty acids are essential fatty acids of the human body, of which docosahexaenoic acid is abundant in brain tissue and plays an important role in promoting brain development. In addition, n-3 polyunsaturated fatty acids are associated with attention deficit hyperactivity disorder (ADHD) and depression And Alzheimer’s disease are closely related. N-3 polyunsaturated fatty acids affect brain development and function of the mechanism involves many aspects, in addition to participating in the organization of cell membranes and through its metabolites to play a role, but also can act on peroxisome proliferator-activated receptor transcription Factors, which in turn regulate the expression of multiple genes; these genes are involved in many aspects of lipid and energy metabolism, cell adhesion, neurotransmitter transport and signal transduction.