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目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠过程中的血氧(SaO_2)变化与事件恢复情况的相关关系。方法:将呼吸事件按照恢复通气情况的不同分为伴随第二事件(SRE,未恢复正常通气)和不伴随第二事件(N-SRE,恢复正常通气)两类,以提取事件后SaO_2变化段的4个特征值作为指标,比较不同病情的患者各血氧指标的差异性,以及个体内归一化后SRE血氧变化组和N-SRE血氧变化组各指标的对比。结果:SRE血氧变化组和N-SRE血氧变化组成对t检验的结果显示,SRE组SaO_2的下降程度、氧降速率、持续时间都要极显著大于N-SRE组(P<0.01),SRE组SaO_2的下降最低值极显著小于N-SRE组(P<0.01)。中度和重度患者的血氧指标对比均具有显著性差异。结论:OSAHS患者的不同病情会影响SaO_2的相关指标的变化,且SaO_2的相关指标和事件恢复情况存在相关关系。本研究为呼吸事件恢复的进一步研究提供更多的依据,了解如何能从呼吸事件中较快恢复正常通气为治疗OSAHS提供可能的方案。
Objective: To investigate the relationship between the change of blood oxygen (SaO_2) during sleep and the recovery of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: Breathing events were divided into two groups (SRE, no normal ventilation) and no secondary events (N-SRE, normal ventilation) The four eigenvalues were used as indexes to compare the difference of each oxygen index of patients with different disease conditions and the comparison of each index between normalized SRE blood oxygenation group and N-SRE blood oxygenation group. Results: The results of t test showed that the decrease of SaO_2, the rate of oxygen descent and the duration of oxygen desaturation in SRE group were significantly greater than those in N-SRE group (P <0.01) The lowest decrease of SaO_2 in SRE group was significantly less than that in N-SRE group (P <0.01). Moderate and severe patients in the blood oxygen indicators were significant differences. Conclusion: The different conditions of patients with OSAHS may affect the changes of SaO 2 related indicators, and the correlation between SaO 2 related indicators and event recovery. This study provides further evidence for further research on resuscitation of respiratory events and shows how it is possible to recover from normal respiratory events from respiratory events for the treatment of OSAHS.