目的　介绍 1984年至 2 0 0 1年经蝶入路切除 2 0 6例巨大垂体腺瘤的手术操作技术和经验。方法　 2 0 6例巨大垂体腺瘤患者 ,男性 12 1例 ,女性 85例 ,采用经蝶显微外科手术。结果　本组患者肿瘤全切除 137例 ,次全切除 4 4例 ,大部切除 2 5例 ,其中死亡 2例。结论　对巨大垂体腺瘤而言 ,经蝶窦显微外科手术不但比经颅手术安全 ,而且切除范围也比经颅手术彻底 ,对视觉功能的改善更优于经颅手术 Objective To introduce surgical techniques and experience in the surgical removal of 206 giant pituitary adenomas by transsphenoidal approach from 1984 to 2001. Methods Twenty-six patients with giant pituitary adenoma, including 12 males and 85 females, were treated with transsphenoidal microsurgery. Results Totally 137 patients underwent total resection of tumors in this group, 44 cases were subtotally resected, 25 cases were mostly resected, of which 2 died. Conclusions For giant pituitary adenomas, microsurgical transsphenoidal microsurgery is not only safer than transcranial surgery, but also has a better resection range than transcranial surgery and better visual function improvement than transcranial surgery