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目的研究ｐ１６蛋白在膀胱癌组织中的表达，探讨其对膀胱癌的生物学行为和预后的意义。方法应用免疫组化法对５０例膀胱癌和４１例膀胱癌癌旁组织进行比较，观察ｐ１６蛋白表达情况。结果（１）膀胱癌组织中ｐ１６蛋白阳性率为４４．００％，明显低于膀胱癌癌旁组织的阳性率（７３．１７％，Ｐ＜０．０１）；（２）ｐ１６蛋白在Ⅰ、Ⅱ、Ⅲ级肿瘤中的阳性表达率分别为６６．６７％，５２．９４％，２３．８１％（Ⅰ和Ⅲ级比，Ｐ＜０．０５）。在Ｔｉｓ－Ｔ１、Ｔ２－Ｔ４期肿瘤中分别为６６．６７％，３４．２８％（Ｐ＜０．０５）。在未复发组、存活组的表达率显著高于复发组、死亡组（Ｐ＜０．０１）；（３）ｐ１６蛋白失表达可能发生在膀胱癌晚期阶段。结论ｐ１６蛋白在抑制膀胱癌的发生、发展中起重要作用
Objective To study the expression of p16 protein in bladder cancer and to explore its significance on the biological behavior and prognosis of bladder cancer. Methods Immunohistochemistry was used to compare the expression of p16 in 50 cases of bladder cancer and 41 cases of bladder cancer adjacent tissues. Results (1) The positive rate of p16 protein in bladder cancer was 44.00%, which was significantly lower than that in adjacent tissues of bladder cancer (73.17%, P <0.01). (2) The positive expression rate of grade Ⅱ and Ⅲ tumors were 66.67%, 52.94% and 23.81% respectively (Ⅰ and Ⅲ, P <0.05). In Tis-T1, T2-T4 tumors were 66.67%, 34.28% (P <0.05). In non-relapsed group, the expression rate of survivors was significantly higher than that in recurrence group and death group (P <0.01). (3) The loss of p16 protein expression may occur in the late phase of bladder cancer. Conclusion p16 protein plays an important role in inhibiting the occurrence and development of bladder cancer