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探讨并研究载脂蛋白E(ApoE)的基因多态性与插管全麻下不同分级血压之间的相关性.运用等电聚焦电泳 -免疫印迹法测定ApoE的表型,探讨插管全麻下老年患者不同血压等级ApoE基因多态性的影响.ApoE表型中以E3/3最为常见,ApoE等位基因中E3的频率分布最高;不同的ApoE表型,E4等位基因携带者的血压变化较其他等位基因携带者的血压变化大(P<0.05).麻醉医生应充分了解患者不同ApoE表型的差别,结合自身临床经验,对E4高危人群的插管全麻进行无缝隙的围手术期血压管理.“,”To investigate and study the association between apolipoprotein E(ApoE)gene polymorphism and different graded blood pressure under general anesthesia,the phenotypes of ApoE were determined by isoelectric focusing electrophoresis and Western blotting.The effects of ApoE gene polymorphism at different blood pressure levels in elderly patients under general anesthesia were explored.E3/3 was the most common phenotype in the ApoE phenotype.The frequency distribution of E3 in the ApoE allele was the highest;the blood pressure changes in the ApoE phenotype and e4 allele carriers were greater than those in other allele carriers(P<0.05).Anesthesiologists should fully understand the differences in patients with different ApoE phenotypes,combined with their own clinical experience,perform seamless perioperative blood pressure management for intubated general anesthesia in E4 high-risk groups.